Ameela is a viscoelastic, sterile, non-pyrogenic, absorbable intradermal injectable solution, based on polymerized polynucleotides. The polynucleotides used in Ameela are purified, making them free from other components, such as proteins, which can trigger an immune response. It is an innovative and effective way to restore skin firmness and elasticity, and ensure healthy skin that is protected against free radicals and cellular damage.

Ameela Polynucleotides is a viscoelastic, sterile, non-pyrogenic, absorbable intradermal injectable solution, based on polymerized polynucleotides. The polynucleotides used in Ameela are purified, making them free from other components, such as proteins, which can trigger an immune response. It is an innovative and effective way to restore skin firmness and elasticity, and ensure healthy skin that is protected against free radicals and cellular damage.

Both our PN and PDRN are DNA-based molecules derived from Wild Salmon DNA, but they differ in molecular size and biological function.

PN (Polynucleotides) are long-chain DNA fragments (>1500 kDa), consisting of full or partially hydrolysed nucleotides.

PDRN (Polydeoxyribonucleotide) is a shorter DNA fragment (50–1500 kDa), making it a low-molecular-weight subtype of PN.

Yes. Ameela Polynucleotides can be safely used after superficial to medium-depth peels to support healing, reduce inflammation and enhance tissue regeneration. It is best applied post-peel once any erythema or peeling begins to settle (typically 3-5 days after). Avoid injecting immediately after deep chemical peels to prevent irritation.

Ameela Exosomes is a next-generation treatment designed to rejuvenate and restore the skin through a powerful synergy of active ingredients. Each 3ml syringe delivers 40 billion plant-derived exosomes that regulate inflammation and oxidative stress, alongside 50mg of PDRN to stimulate tissue repair, angiogenesis and collagen synthesis. The formulation also includes growth factors that activate renewal pathways, Ameela collagen to reinforce dermal structure and hydration and Hexapeptide-8 to gently relax expression lines. Together, these components offer a comprehensive, non-invasive solution for brighter, firmer and more resilient skin.

Ameela Face is a Polymerised Polynucleotide Gel that improves skin tone and elasticity, reduces wrinkles and fine lines, and results in faster healing and improvement skin structure as a post-surgery treatment.

Yes, but with appropriate timing. Ameela Eyes can be used to support post-blepharoplasty healing, reduce bruising and improve skin quality around the periocular area. Injections should be performed after the initial healing phase, typically 2-3 weeks post-op, once sutures are removed and tissue integrity is restored. Always consult with the surgeon for clearance.

Ameela uses plant-derived exosomes for their superior safety profile, biocompatibility and sustainability. Unlike other derived exosomes, plant exosomes carry no risk of zoonotic transmission, immunogenicity or ethical concerns. They also possess unique phytochemical cargo that modulates oxidative stress and inflammation - key drivers of skin aging.

Both PN and PDRN are effective, but their delivery mechanisms differ based on molecular size.

PDRN, with its lower molecular weight (50–1500 kDa), is better suited for topical or superficial delivery, especially when applied with microneedling or incorporated into exosome-based formulations.

PN, being larger (>1500 kDa), is best delivered via intradermal injection, allowing it to act as a structural biostimulator within the extracellular matrix.

In short, both work well - PDRN excels in surface-level regenerative treatments, while PN is ideal for deeper dermal remodeling through injectable protocols.

The recommended methodology is via intradermal microinjections, using a 30G or 32G needle, with a depth of 1-2 mm, depending on the treatment area. The point-by-point technique or nappage method can be used for even distribution. For the periocular region, smaller volumes and precision delivery are recommended. Injection allows the PN to reach the target layer (papillary dermis) for optimal fibroblast stimulation and ECM remodeling.

They share similar regenerative effects, but act through different mechanisms:

PDRN binds to A2A adenosine receptors, stimulating angiogenesis, fibroblast proliferation and anti-inflammatory signalling.

PN acts more structurally, improving cellular hydration, enhancing ECM integrity and supporting DNA repair and fibroblast activation through prolonged residence in the tissue.

Learn about what is Ameela Face treatment in our training programs under 'Ameela® training' for professionals.

Ameela Exosomes is a multi-phase regenerative formula combining plant-derived actives, primarily from grapefruit and watermelon exosomes, alongside PDRN, growth factors Hexapeptide-8 and Ameela collagen.

The duration of the effects of Ameela Polynucleotides treatment can vary depending on individual factors such as the patient's skin type, age, lifestyle, and the extent of periocular concerns being addressed.

Generally, patients may begin to see initial improvements shortly after treatment, with the effects typically lasting several months. It's important to note that two to three sessions is necessary to achieve and maintain the desired results. For a more accurate assessment of how long the results may last for a specific patient, a consultation with a healthcare professional is advised.

- For Eyes – Ameela® Eyes or Ameela® Rejuvenation

- For Face – Ameela® Rejuvenation or Ameela® Face

- For Hair – Ameela® Rejuvenation

- For Neck – Ameela® Rejuvenation

Both are biologically active but in different ways:

PDRN acts as a receptor agonist, directly activating cell signalling for angiogenesis, anti-inflammation and tissue repair.

PN provides structural support to the extracellular matrix (ECM), enhances cell hydration and promotes slow, sustained fibroblast activity.

The two are complementary rather than competitive.

There is absolutely no difference between Nucleadyn and Ameela®, we have just rebranded, but the product is exactly the same Ameela® Eyes, Ameela® Rejuvenation and Ameela® Face.

Yes, RF microneedling induces controlled dermal injury, triggering collagen remodeling, while Ameela polynucleotides accelerate healing, reduce post-inflammatory response and stimulate deeper regeneration. The PN should be injected 48-72 hours after RF microneedling, once acute inflammation subsides, or in some cases can be used prior as a skin primer. Avoid injecting immediately after RF to reduce risk of irritation or over-inflammation.

Ameela Face Polynucleotide is a long-lasting treatment that reduces wrinkles, skin quality and it is an excellent choice for faster tissue improvement and healing post-surgery. Explore 'Ameela face before and after' testimonials and read through 'Ameela reviews' to witness the transformative impact of Ameela Face. Discover why many consider it a top-tier 'Ameela skin booster'.

Grapefruit & Watermelon Exosomes

Deliver antioxidant-rich mRNA, microRNA and phytochemicals to reduce inflammation, neutralise oxidative stress and stimulate cellular regeneration.

PDRN (Polydeoxyribonucleotide)

Activates A2A receptors to promote angiogenesis, fibroblast proliferation, collagen synthesis and DNA repair.

Growth Factor Mimetics (EGF, IGF-1, VEGF, bFGF, TGF-β)

Support epidermal renewal, enhance collagen production, improve circulation and regulate inflammation.

Hexapeptide-8

Softens dynamic wrinkles by inhibiting SNARE complex formation, mimicking the effects of botulinum toxin without freezing expression.

Ameela Collagen

Provides structural support, enhances dermal hydration and reinforces extracellular matrix integrity for long-term skin firmness and resilience.

Both support vascular regeneration, but through different mechanisms:

PDRN in Ameela Exosomes activates VEGF expression via A2A receptor binding, promoting microcirculation and healing.

PN formula also support angiogenesis over time through fibroblast and ECM remodelling, but work more gradually and deeply.

Yes. There are no systemic contraindications to flying after an Ameela treatment.

Results with Ameela Face are noticeable after each session, and you'll see immediate improvements. For optimal benefits, follow the recommended 2-3 treatments is recommended per patient per area, with two weeks in-between each treatment.

Follow up treatment in 6-8 months - 1-2 treatments in total depending on age, lifestyle and skin quality.

Studies show that plant-derived exosomes can enter keratinocytes and fibroblasts via endocytosis and modulate gene expression. They upregulate antioxidant response elements, downregulate inflammatory cytokines and enhance pathways involved in ECM remodeling and DNA repair.

Orders can be placed through our website, www.ameelaskin.com

PN is ideal for volume restoration, skin density, firmness and elasticity, due to its prolonged stimulation of fibroblasts and ECM renewal.

PDRN is better suited for repair-focused protocols where inflammation, vascular damage, or barrier dysfunction are present.

Yes. PDRN is clinically validated for its regenerative effects in dermatology, including enhanced angiogenesis, fibroblast activation and collagen synthesis, primarily via A2A adenosine receptor stimulation. Studies show significant improvements in skin hydration, elasticity and repair.

Plant-derived exosomes, particularly from grapefruit and watermelon, are supported by emerging data showing their ability to modulate inflammation, reduce oxidative stress and influence gene expression in human skin cells, making them a safe and effective tool in non-invasive skin rejuvenation protocols.

- For Eyes – Ameela® Eyes or Ameela® Rejuvenation

- For Face – Ameela® Rejuvenation or Ameela® Face

- For Hair – Ameela® Rejuvenation

- For Neck – Ameela® Rejuvenation

Yes. Polynucleotides are highly biocompatible, non-immunogenic and well-tolerated. Ameela uses purified DNA fragments derived from Wild Salmon DNA, free from allergens and contaminants. They do not trigger immune rejection and their safety has been established in ophthalmology, orthopedics and dermatology over decades.

If you already have a registered account on the Nucleadyn website, you will be sent new login details to use for Ameela® Skin. If you have not yet registered, please register from the ameelaskin.com website.

PN promotes structural collagen (types I and III) over a longer period by stimulating fibroblast activity and maintaining dermal hydration.

PDRN also supports collagen synthesis but is more focused on wound healing and vascular regeneration, rather than long-term remodelling.

Polynucleotides are strong polyanions with a high affinity for water molecules. When injected, they create a hydrated matrix within the dermis, enhancing tissue turgor and elasticity. This water-binding also improves nutrient diffusion and supports the optimal microenvironment for fibroblast function and ECM activity.

Yes. Each ingredient in the Ameela Exosome formula is scientifically validated, supported by either clinical studies or laboratory research. Every component is carefully selected for safety, performance and proven biological activity.

The source affects purity, biological activity and clinical outcomes. Ameela uses Wild Salmon DNA, which has a superior purity profile compared to farmed sources. Ameela forumaltions are lower in pro-inflammatory residues and higher in bioavailable nucleotides. This leads to better cellular uptake, reduced inflammation and more reliable regenerative signalling.

Please keep using this as normal.

Ameela PN activates multiple regenerative cascades:

PI3K/AKT and MAPK/ERK via fibroblast stimulation → collagen production

TGF-β signalling → ECM remodeling

A2A adenosine receptor activation → angiogenesis and inflammation control

Nrf2 pathway → antioxidant response and ROS neutralisation

Explore our official website for a gallery showcasing impressive before-and-after photos of individuals who have experienced transformations with Ameela Polynucleotides. Witness the visible improvements in skin tone, reduced wrinkles, and overall rejuvenation.

Ameela avoids synthetic peptides and recombinant proteins to maintain full biocompatibility, reduce the risk of allergic reactions and align with a clean ethos. Its naturally sourced components mimic physiological healing processes without triggering artificial overstimulation or long-term dysregulation.

This is absolutely fine - it is exactly the same product.

Yes, absolutely. They are highly complementary.

Use Ameela PN as an injectable base to stimulate fibroblasts, repair the extracellular matrix and restore hydration at depth.

Follow or alternate with Ameela Exosomes to deliver PDRN and other active ingredients that modulate inflammation, enhance healing and reinforce barrier repair.

Yes. Polynucleotides have shown clinical efficacy in accelerating re-epithelialisation, reducing scar formation and supporting tissue regeneration in both aesthetic and medical literature. Their role in modulating inflammation and stimulating matrix repair supports improved healing outcomes.

Please change all mention of Nucleadyn on your website and social channels to Ameela®.

From June 20th we will share access to Instagram content that can be used by all clinics explaining the name change. We can also provide all updated marketing material required post rebrand.

Ameela Exosomes incorporates PDRN (polydeoxyribonucleotide) rather than full-length polynucleotides due to its lower molecular weight (50–1500 kDa) and shorter nucleotide chain length. This molecular size allows for efficient diffusion through the microchannels created in the epidermis and superficial dermis, ensuring greater bioavailability without compromising the structural integrity of the surrounding tissue.

In contrast, full-length polynucleotides (>1500 kDa) exhibit limited permeability in topical protocols and are better suited for injectable delivery where deeper tissue integration is required.

PDRN has direct anti-inflammatory effects, decreasing pro-inflammatory cytokines (e.g., TNF-α, IL-6) and promoting tissue recovery.

PN reduces inflammation more indirectly, through enhanced hydration, ECM repair and improved cellular function over time.

Both are highly biocompatible and non-immunogenic, especially when derived from purified Wild Salmon DNA like in Ameela.

Microneedling is the most appropriate method for delivering Ameela Exosomes due to its ability to transiently disrupt the stratum corneum and create controlled microchannels that reach the papillary dermis. This significantly enhances transdermal diffusion and cellular uptake of exosomes while preserving their lipid bilayer integrity.

Microneedling induces a mild inflammatory response, priming the skin for regeneration. When combined with Ameela Exosomes, this synergistic environment accelerates fibroblast activation, collagen and elastin synthesis, angiogenesis and oxidative stress modulation. Compared to passive topical application, microneedling ensures higher bioavailability and targeted delivery of the exosome formulation.

Polynucleotides are strong polyanions with a high affinity for water molecules. When injected, they create a hydrated matrix within the dermis, enhancing tissue turgor and elasticity. This water-binding also improves nutrient diffusion and supports the optimal microenvironment for fibroblast function and ECM activity.

All rebranded content will be shared with existing clients, and can be shared with new clients on request.

They directly bind A2A adenosine receptors, leading to angiogenesis, anti-inflammatory effects and fibroblast proliferation. Together, they provide both structural and signalling-level regeneration.

All social channels will stay exactly the same. You won't need to find or follow any new accounts, we will simply change the name and handles.

Watermelon and grapefruit exosomes deliver superior skin rejuvenation by combining antioxidant, anti-inflammatory and regenerative actions in a safe, biocompatible formulation. Rich in lycopene and naringenin, they reduce oxidative stress, brighten skin and protect collagen. Their plant-derived mRNA and microRNA activate fibroblasts and repair pathways, enhancing firmness, tone and resilience - without the variability or risks associated with human-derived exosomes.

Ameela Exosomes may be ideal for you if you are experiencing signs of skin fatigue such as dullness, reduced elasticity, uneven tone, low-grade inflammation, or damage from environmental stressors like UV exposure and pollution. This advanced formulation works to restore skin radiance, firmness and overall cellular balance.

PNs downregulate Matrix Metalloproteinases (e.g., MMP-1, MMP-12) - enzymes responsible for ECM degradation and upregulate TIMPs (Tissue Inhibitors of Metalloproteinases). This dual regulation slows collagen breakdown and promotes balanced remodeling, particularly important in aged, UV-damaged, or photo-sensitive skin.

Please get in touch with any further questions or enquiries.

Email: info@ameelaskin.com

Office: +44 (0)203 883 7001

No. Ameela polynucleotides are non-coding, fragmented DNA strands that do not integrate into the host genome. They serve as temporary extracellular regulators and are broken down into harmless nucleotides by endogenous enzymes. There is no mutagenic risk associated with their use.

Results can be seen from the first session in terms of hydration, glow and reduced inflammation. Cellular-level improvements in collagen synthesis, texture and tone typically emerge within 2–4 weeks, with cumulative effects seen over a course of 3–5 treatments.

PNs influence gene transcription by acting as external modulators of nuclear signalling, enhancing expression of genes related to collagen I/III production, fibronectin, hyaluronic acid synthase and anti-inflammatory cytokines. They also downregulate inflammatory mediators like IL-6 and TNF-α, creating a regenerative microenvironment that favours tissue repair and dermal thickening.

Ameela PN works by directly stimulating fibroblast activity, enhancing collagen/elastin synthesis, improving dermal hydration and reinforcing ECM structure over time.

Ameela Exosomes modulate cell-to-cell communication, reduce oxidative stress and inflammation (via plant-derived exosomes) and enhance tissue repair via PDRN and growth factors.

Ameela Rejuvenation is a cutting-edge treatment that harnesses the regenerative power of polynucleotides to restore skin's elasticity, reduce wrinkles, and improve overall skin health. This non-invasive treatment rejuvenates the skin on the face, neck, hair, and hands, offering a comprehensive solution to signs of aging.

Ameela Polynucleotides are injected directly into the mid to deep dermis, making them ideal for structural skin regeneration, collagen stimulation and long-term tissue remodelling.

Ameela Exosomes, though not injected, are applied with microneedling, allowing its lower molecular weight actives (like PDRN) and plant exosomes to penetrate the epidermis and superficial dermis through microchannels.

No - Ameela Exosomes do not replace PN injections. While exosomes and PDRN offer anti-inflammatory and reparative benefits, they do not penetrate deep enough or remain in the dermis long enough to match the structural biostimulation of injected PN. They are best used in tandem or between PN treatments.

The Ameela Rejuvenation treatment offers numerous benefits:

- Wrinkle Reduction: Significant decrease in wrinkles and fine lines.

- Skin Tone Improvement: Restores and enhances natural skin tone.

- Elasticity Restoration: Increases skin elasticity for a youthful appearance.

- Hydration Boost: Addresses dehydration, especially in the delicate periocular area.

- Minimal Downtime: Quick, non-invasive sessions with lasting results.

Ameela Rejuvenation is only available if you are a Healthcare Professional looking to purchase products or require training. If you are looking to receive more information regarding Ameela and treatments please contact us.

Explore our official website for a gallery showcasing impressive before-and-after photos of individuals who have experienced transformations with Ameela Rejuvenation. Witness the visible improvements in skin tone, reduced wrinkles, and overall rejuvenation.

Ameela Eyes is a non-invasive polynucleotide-based gel treatment designed specifically for the delicate eye area. It helps reduce the appearance of under-eye puffiness, smooth fine lines around the eyes, and visibly supports skin tone and texture in the periocular region.

Formulated with advanced polynucleotide technology, the gel supports microcirculation, promotes a brighter, more refreshed look, and helps protect against oxidative stress. By enhancing the skin’s natural hydration and radiance, Ameela Eyes contributes to a youthful, well-rested appearance.

This treatment can be used on its own for cosmetic rejuvenation or as part of a pre- and post-treatment skincare protocol to support overall skin quality around the eyes

The duration of the effects of Ameela Eyes treatment can vary depending on individual factors such as the patient's skin type, age, lifestyle, and the extent of periocular concerns being addressed.

Generally, patients may begin to see initial improvements shortly after treatment, with the effects typically lasting several months. It's important to note that two to three sessions is necessary to achieve and maintain the desired results. For a more accurate assessment of how long the results may last for a specific patient, a consultation with a healthcare professional is advised.

No, Ameela Eyes is not a filler. Instead, it is a polynucleotide-based gel treatment designed to rejuvenate the periocular area. Unlike fillers that physically add volume to the skin, Ameela Eyes works by promoting the natural radiance and hydration of skin.

Physicians interested in offering Ameela Eyes as a treatment option can purchase it directly through our website. Click on the first button above to order your product.